In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation

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In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation.

The present study investigates the differential effect of two vitamin D receptor agonists, calcitriol and paricalcitol, on human aortic smooth muscle cells calcification in vitro. Human vascular smooth muscle cells were incubated in a high phosphate (HP) medium alone or supplemented with either calcitriol 10(-8)M (HP + CTR) or paricalcitol 3·10(-8) M (HP + PC). HP medium induced calcification, ...

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Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells

BACKGROUND Vascular calcification (VC) is prevalent in patients suffering from chronic kidney disease. Factors promoting calcification include abnormalities in mineral metabolism, particularly high phosphate levels. Inorganic phosphate (Pi) is a classical inducer of in vitro VC. Recently, an inverse relationship between serum magnesium concentrations and VC has been reported. The present study ...

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ژورنال

عنوان ژورنال: American Journal of Physiology-Renal Physiology

سال: 2012

ISSN: 1931-857X,1522-1466

DOI: 10.1152/ajprenal.00684.2011